An Overview of Drug Development and Enobia's ENB-0040 Trial Status
CR Greenberg, et al. Life-Threatening Hypophosphatasia in Infants and Young Children: Results of Long-Term Treatment with ENB-0040, a Bone-Targeted, Enzyme Replacement-Therapy (ERT), and An Algorithm For Patient Management. 2010 ASHG, Abst. 13.
MP Whyte, et al. Hypophosphatasia in Children: Enzyme Replacement Therapy Using Bone-Targeted, Tissue-Nonspecific Alkaline Phosphatase. 2010 ASHG, Abst. 3070.
Skrinar A, Smith J, Patel C, Landy H. Disease Severity in Children and Adults with Hypophosphatasia (HPP). 2010 ASHG, Abst. 2024.
Skrinar A, Smith J, Smith S, Landy H., Burden of Illness in Children and Adults with Hypophosphatasia. 2010 ACMG, Abst. 255.
Landy H, Lemire I, Blond L, Loisel TP, Boileau G, Millán JL, Léonard P, and Crine P. (2009) Dose-dependent improvements of the hypophosphatasia phenotype in Akp2-/- mice following the administration of ENB-0040 [abstract; program #3138]. Presented at the 59th Annual Meeting of the American Society of Human Genetics.
Wenkert D, Zhang F, Benigno MC, Zerega JA, Mack KE, Lim V, Coburn SP, Ericson K, McAlister WH, Mumm S, and Whyte MP. (2009) Hypophosphatasia: Natural history of 177 pediatric patients [abstract; program #65]. Presented at the 59th Annual Meeting of the American Society of Human Genetics.
Whyte MP, Greenberg CR, Edgar T, Van Sickle BJ, Hamdan M, Salman N, Bober M, McAlister WH, Wenkert D, Landy H. (2009) Hypophosphatasia: Treatment of life-threatening disease using bone-targeted human recombinant tissue non-specific alkaline phosphatase [abstract; program #138]. Presented at the 59th Annual Meeting of the American Society of Human Genetics.
Wenkert D, Zhang F, Benigno MC, Zerega JA, Mack KE, Lim VT, Coburn SP, Ericson K, McAlister WH, Mumm S, and Whyte MP. (2009) Hypophosphatasia: Natural history of 177 pediatric patients [abstract; presentation #878, poster #229]. Presented at the 73rd Annual Scientific Meeting of the American College of Rheumatology.
Whyte MP, Greenberg CR, Edgar T, Van Sickle BJ, Hamdan M, Salman NJ, Bober MB, McAlister WH, Wenkert D, and Landy H. (2009) Hypophosphatasia: Treatment of life-threatening disease using bone-targeted human recombinant tissue non-specific alkaline phosphatase [abstract; presentation #877, poster #228]. Presented at the 73rd Annual Scientific Meeting of the American College of Rheumatology.
Lemire I, Blond L, Loisel TP, Boileau G, Millan JL, Léonard P, and Crine P. (2009) Dose-dependent improvements of the hypophosphatasia phenotype in Akp2-/- mice following the administration of ENB-0040 [abstract]. J Bone Miner Res 24 (Suppl 1). Presented at the 31st Annual Meeting of the American Bone and Mineral Society.
Wenkert D, Benigno M, Mack K, McAlister W, Mumm S, and Whyte MP. (2009). Hypophosphatasia: Prevalence of clinical problems in 175 pediatric patients [abstract]. J Bone Miner Res 24 (Suppl 1). Presented the 31st Annual Meeting of the American Bone and Mineral Society.
Whyte MP, Greenberg C, Edgar T, Van Sickle B, Hamdan M, Salman N, Bober M, McAlister W, Wenkert D, and Landy H. (2009). Hypophosphatasia: Treatment of life-threatening disease using bone-targeted human recombinant tissue non-specific alkaline phosphatase [abstract]. J. Bone Miner Res 24 (Suppl 1). Presented at the 31st Annual Meeting of the American Bone and Mineral Society.
Whyte M, Zhang F, Benigno M, Zerega J, Mack K, Lim V, Coburn A, Ericson K, McAlister W, Mumm S, and Wenkert D. (2009). Hypophosphatasia: Natural history of 177 pediatric patients [abstract]. J. Bone Miner Res 24 (Suppl 1). Presented at the 31st Annual Meeting of the American Bone and Mineral Society.
Greenberg CR, Mhanni A, Catte D, Kishnani P, Weber T, McGinn M, Craig S, McAlistair W, Landy H, and Whyte MP. (2009). Interim results of adults and infants with hypophosphatasia treated with bone-targeted human recombinant alkaline phosphatase ENB-0040 [abstract]. Presented at the 11th International Congress of Inborn Errors of Metabolism.
Whyte, MP, Landy H, Edgar T, Weber T, Kishnani P, Wenkert D, McAlister WH, Bauer ML, Van Sickle BJ, Salman N, Hamdan M, and Rockman-Greenberg C. (2009). ENB-0040, a bone-targeted human recombinant tissue nonspecific alkaline phosphatase (TNSALP) fusion protein, in the treatment of infants and adults with hypophosphatasia [abstract]. Presented at the 5th International Conference on Children’s Bone Health.
Whyte, MP, Landy H, Edgar T, Weber T, Kishnani P, Wenkert D, McAlister WH, Bauer ML, Van Sickle BJ, and Rockman-Greenberg C. (2009). Hypophosphatasia: Enzyme replacement therapy with ENB-0040, a bone-targeted human recombinant tissue nonspecific alkaline phosphatase (TNSALP) fusion protein [abstract; presentation #S21-3]. Presented at The Endocrine Society’s 91st Annual Meeting.
Greenberg CR, Mhanni A, Catte D, Kishnani P, Weber T, McGinn M, Craig S, McAlister WH, Landy H, and Whyte MP. (2009). First report of promising treatment of an infant with severe hypophosphatasia with bone-targeted human recombinant alkaline phosphatase [abstract]. Presented at the 2009 Garrod Association Annual Symposium.
