Hypophosphatasia

A rare, inherited, and sometimes fatal metabolic bone disease characterized by poor bone mineralization and profound skeletal defects.Hypophosphatasia (HPP) is a rare, inherited, and sometimes fatal bone disease characterized by low serum alkaline phosphatase activity and skeletal dysplasia characterized by skeletal Relating to a deficiency of minerals.hypomineralization. Symptoms include failure to thrive, respiratory insufficiency, A softening of bones in children leading to fractures and deformity, which is predominantly caused by a vitamin D deficiency.rickets, myopathy and seizures in infants; rickets, myopathy, poor growth, non-traumatic fractures and early loss of primary teeth in children; and The adult form of rickets, which is a softening of the bones caused by defective bone mineralization.osteomalacia or "soft bones", frequent non-traumatic fractures, bone pain and early permanent tooth loss in adults.