Individuals with A rare, inherited, and sometimes fatal metabolic bone disease characterized by poor bone mineralization and profound skeletal defects.hypophosphatasia (HPP) present with a wide range of symptoms, which can prove challenging for clinicians to diagnose.
HPP shares a number of symptoms with other conditions or diseases, depending on the age at diagnosis. Clinical diagnostic testing assists clinicians in making the proper diagnosis.
- In the perinatal form, HPP shares symptoms with thanatophoric dysplasia, campomelic dysplasia, and achondrogenesis.
- In the infantile and childhood forms, HPP shares symptoms with inborn errors of energy metabolism, A softening of bones in children leading to fractures and deformity, which is predominantly caused by a vitamin D deficiency.rickets, neglect, and child abuse.
- In the adult form or in odontohypophosphatasia, HPP shares symptoms with osteoarthritis, osteoporosis, and periodontal disease.
